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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
34.85
Human Site:
Y390
Identified Species:
54.76
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
Y390
K
L
D
A
D
K
S
Y
Q
C
L
K
E
T
C
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
Y390
K
L
D
A
D
K
S
Y
Q
C
L
K
E
T
C
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
Y390
K
L
D
A
D
K
S
Y
Q
C
L
K
E
T
C
Dog
Lupus familis
XP_852191
460
52810
Y374
K
L
D
A
D
K
S
Y
Q
C
L
K
E
T
C
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
Y390
K
L
D
A
D
K
S
Y
Q
C
L
K
E
T
F
Rat
Rattus norvegicus
Q91ZN7
476
54410
Y390
K
L
D
A
D
K
S
Y
Q
C
L
K
E
T
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
Y390
K
L
D
A
D
R
S
Y
H
C
L
K
E
T
C
Chicken
Gallus gallus
Q8AYC9
476
53830
Y390
K
L
D
A
D
G
S
Y
R
S
L
R
D
V
C
Frog
Xenopus laevis
Q6DE87
474
53957
Y389
K
V
N
A
E
S
S
Y
S
N
L
M
D
T
C
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
Q341
A
L
G
H
T
W
K
Q
S
C
N
N
Q
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
V402
Q
N
Y
F
Q
R
L
V
R
R
M
T
R
F
F
Honey Bee
Apis mellifera
XP_623436
467
53927
Y388
L
K
D
E
N
Y
T
Y
R
I
S
N
F
G
T
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
L410
R
E
T
D
D
Y
R
L
L
V
T
W
R
E
V
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
D390
K
V
L
T
T
T
L
D
K
L
P
I
Y
S
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
V351
K
G
A
A
N
D
L
V
Q
K
I
E
E
A
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
60
46.6
13.3
N.A.
0
13.3
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
80
73.3
20
N.A.
26.6
33.3
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
67
0
0
0
0
0
0
0
0
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
54
0
0
0
0
47
% C
% Asp:
0
0
60
7
60
7
0
7
0
0
0
0
14
0
0
% D
% Glu:
0
7
0
7
7
0
0
0
0
0
0
7
54
7
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
7
7
20
% F
% Gly:
0
7
7
0
0
7
0
0
0
0
0
0
0
7
0
% G
% His:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
7
7
7
0
0
0
% I
% Lys:
74
7
0
0
0
40
7
0
7
7
0
47
0
0
0
% K
% Leu:
7
60
7
0
0
0
20
7
7
7
60
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
0
% M
% Asn:
0
7
7
0
14
0
0
0
0
7
7
14
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% P
% Gln:
7
0
0
0
7
0
0
7
47
0
0
0
7
0
0
% Q
% Arg:
7
0
0
0
0
14
7
0
20
7
0
7
14
0
0
% R
% Ser:
0
0
0
0
0
7
60
0
14
7
7
0
0
7
7
% S
% Thr:
0
0
7
7
14
7
7
0
0
0
7
7
0
54
14
% T
% Val:
0
14
0
0
0
0
0
14
0
7
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
7
0
0
7
% W
% Tyr:
0
0
7
0
0
14
0
67
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _